Impact of estimated dose of radiation to immune cells (EDRIC) in locally advanced Non-Small-Cell lung Cancer: A secondary analysis of the multicenter randomized PET-Plan trial
Higher doses of radiation to the immune system were associated with worse PFS in this secondary analysis of the PET-Plan trial. The omission of elective nodal irradiation did not influence EDRIC. MBD could potentially suffice as a surrogate for EDRIC, as it is more readily available and requires fewer calculations. Future trials should aim to refine existing models and investigate ways to reduce EDRIC to limit its effects in patients undergoing cCRT for locally advanced NSCLC.
Authors
- Jörg Sahlmann (ORCID: https://orcid.org/0000-0003-3023-3318)
- Matthias Miederer (ORCID: https://orcid.org/0000-0001-5075-5995)
- Abdelkhalek Hammi (ORCID: https://orcid.org/0000-0002-4001-1180)
- Harald Binder (ORCID: https://orcid.org/0000-0002-5666-8662)
- Eleni Gkika (ORCID: https://orcid.org/0000-0001-5455-252X)
- Cas Stefaan Dejonckheere (ORCID: https://orcid.org/0000-0003-4527-4024)
- Michael Tobias Engelhart
- Alexander Brose (ORCID: https://orcid.org/0000-0001-8033-6855)
- Anca-Ligia Grosu (ORCID: https://orcid.org/0000-0003-2255-2255)
- J. König (ORCID: https://orcid.org/0000-0003-4683-0360)
- Andreas Rimner (ORCID: https://orcid.org/0000-0002-1214-3856)
- Markus Hecht (ORCID: https://orcid.org/0000-0003-2082-216X)
- Cornelius F. Waller (ORCID: https://orcid.org/0000-0002-5777-0212)
- Younèss Nour (ORCID: https://orcid.org/0000-0002-3303-048X)
- Sonja Adebahr
- Tanja Schimek‐Jasch (ORCID: https://orcid.org/0000-0003-2027-9320)
- Severin Schmid (ORCID: https://orcid.org/0000-0001-8077-082X)
- Ursula Nestle
- Simeon Ari Barth
Institutions
- University of Freiburg (DE)
- Universitätsklinikum Gießen und Marburg (DE)
- University Hospital Bonn (DE)
- University Medical Center Freiburg (DE)
- Saarland University (DE)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.radonc.2025.110907
- Citations
- 2
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Deutsche Krebshilfe