Similar Allele Frequencies of Two Pathogenic<i>NF2</i>variants in Each of Nine Sporadic Vestibular Schwannomas
This finding may indicate that the two inactivating <i>NF2</i> variants occurred shortly after one another, leaving no room for the Schwann cells with one inactivating <i>NF2</i> variant to expand. Alternatively, the variants occurred in a late development stage whereas Schwann cells do not expand anymore or expand only extremely slowly. In addition, our finding suggests that Schwann cells with one inactivating variant do not gain a growth advantage.
Authors
- Lan Kluwe (ORCID: https://orcid.org/0000-0001-9919-4551)
- Said Farschtschi (ORCID: https://orcid.org/0000-0002-3596-5932)
- Maria Breun (ORCID: https://orcid.org/0000-0001-7548-9451)
- Tim Schulz
- Cordula Matthies (ORCID: https://orcid.org/0000-0002-1729-9411)
- Carmelia-Maria Monoranu
- Thomas Härtung (ORCID: https://orcid.org/0000-0003-1359-7689)
- Ralf-Ingo Ernestus
Institutions
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Universitätsklinikum Würzburg (DE)
Publication Details
- Journal
- Cancer Genomics & Proteomics
- Published
- 2025-04-25
- DOI
- https://doi.org/10.21873/cgp.20516
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 0.00