Culture-negative liver abscess identified with plasma microbial cell-free DNA sequencing: A case report
Pyogenic liver abscess (PLA) is a potentially life-threatening disease. Early diagnosis and appropriate treatment are crucial to ensure high-quality healthcare for patients with PLA. However, this is complicated by their non-specific clinical symptoms. In addition, the etiologic organisms responsible for PLA are frequently culture-negative, thus complicating clinical decision-making. Here, we report a case of PLA caused by <i>Streptococcus intermedius,</i> as identified via DNA metagenomic sequencing of plasma.
Authors
- Rong Fang (ORCID: https://orcid.org/0000-0003-0213-0960)
- Filipe M. Cerqueira (ORCID: https://orcid.org/0000-0003-4438-7959)
- Yuanchao Xue (ORCID: https://orcid.org/0000-0002-8113-2333)
- Natalie Williams‐Bouyer (ORCID: https://orcid.org/0000-0001-9948-8525)
- Heather L. Stevenson (ORCID: https://orcid.org/0000-0002-0645-7621)
Institutions
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Infectious Medicine
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.imj.2025.100180
- Primary Topic
- Amoebic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Texas Medical Branch
- University of Texas Medical Branch at Galveston