Developmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition
We report the first demonstration that DEL-1 significantly ameliorates colonic inflammation in colitis mice. Our findings elucidate a novel mechanism wherein DEL-1 exerts its protective effects by suppressing the Cmpk2-cGAS-STING pathway and promoting reparative macrophage transition. These results collectively position DEL-1 as a promising therapeutic avenue for IBD.
Authors
- Qinyu Feng
- Meihui Tao (ORCID: https://orcid.org/0000-0002-1334-537X)
- Junfa Chen
- Yu Fu (ORCID: https://orcid.org/0000-0002-8960-5000)
- Li Wang (ORCID: https://orcid.org/0000-0003-3984-2494)
- Wei Yan (ORCID: https://orcid.org/0009-0002-4403-1098)
- Xi Zhao (ORCID: https://orcid.org/0000-0002-7513-2476)
- Mengfan Tang
- Chaoyue Chen (ORCID: https://orcid.org/0000-0002-8495-2185)
- Rong Lin (ORCID: https://orcid.org/0000-0001-7327-0835)
- Jingyue Zhang (ORCID: https://orcid.org/0009-0000-4716-2902)
- Yanping Wang (ORCID: https://orcid.org/0000-0003-1723-747X)
Institutions
- University of Science and Technology of China (CN)
- Union Hospital (HK)
- Wuhan Union Hospital (CN)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.jare.2025.04.030
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province