Development and validation of a cephalosporin allergy clinical decision rule
Utilising the previously published and internationally validated tool PEN-FAST, we validated the same criteria with minor modifications for low-risk cephalosporin allergies. The results suggest that a CEPH-FAST score of less than three is associated with a high negative predictive value and could be used by clinicians and antimicrobial stewardship programmes to identify patients with low-risk cephalosporin allergies at the point of care, following local validation, who could proceed to DOC or use non-cross-reactive cephalosporins.
Authors
- Elise Mitri (ORCID: https://orcid.org/0000-0002-1250-2847)
- Moneerah AlGassim (ORCID: https://orcid.org/0000-0002-6612-6963)
- Jamma Li (ORCID: https://orcid.org/0000-0002-2044-2733)
- Grace Koo (ORCID: https://orcid.org/0000-0002-0415-5718)
- Fionnuala Cox (ORCID: https://orcid.org/0000-0002-9183-2683)
- Sara Vogrin (ORCID: https://orcid.org/0000-0002-1597-9421)
- Joseph De Luca (ORCID: https://orcid.org/0000-0001-6541-5512)
- Mark E. Rose (ORCID: https://orcid.org/0000-0003-4724-745X)
- Jason A. Trubiano (ORCID: https://orcid.org/0000-0002-5111-6367)
- Richard Sullivan (ORCID: https://orcid.org/0000-0001-7176-1673)
- Natasha E. Holmes (ORCID: https://orcid.org/0000-0001-8501-4054)
- Ana Maria Copaescu (ORCID: https://orcid.org/0000-0002-9183-5032)
- Suran L. Fernando (ORCID: https://orcid.org/0000-0003-0539-3176)
- Elizabeth J. P. Phillips
- Christian D. Stone
- Chua Kyl
Institutions
- Royal North Shore Hospital (AU)
- McGill University Health Centre (CA)
- Peter Doherty Institute (AU)
- St George Hospital (AU)
- Austin Health (AU)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.jinf.2025.106495
- Citations
- 9
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 12.55
Funders
- Austin Health