Multi-omics analysis unveils a four-gene prognostic signature in esophageal squamous carcinoma and the therapeutic potential of PKP1
We conclude that the CCND1-PKP1-JUP-ANKRD12 signature may serve as a novel indicator for ESCC prognosis and diagnosis. PKP1 expression might provide new clues for gene therapy efficacy in multiple cancers.
Authors
- Feifei Liang (ORCID: https://orcid.org/0000-0002-6114-1013)
- Yutong Zhao (ORCID: https://orcid.org/0000-0001-6604-9315)
- Guiying Sun (ORCID: https://orcid.org/0000-0002-6717-7228)
- Liping Dai (ORCID: https://orcid.org/0000-0002-1910-7591)
- Peng Wang (ORCID: https://orcid.org/0000-0002-2972-7495)
- Tao Li (ORCID: https://orcid.org/0000-0002-5108-1774)
- Wang Zhi (ORCID: https://orcid.org/0000-0003-0226-7641)
- Han Wang (ORCID: https://orcid.org/0000-0003-1247-9859)
- Xiuzhi Zhang (ORCID: https://orcid.org/0000-0002-8080-8135)
- Hua Ye
Institutions
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
- Henan Cancer Hospital (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1186/s12885-025-14150-8
- Citations
- 3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.42