A Comprehensive Study of Guanylate-Binding Protein Family Members as Prognostic marker in Breast Cancer

Background: Breast cancer (BrCa) is the most prevalent tumor among women globally, aside from nonmelanoma skin malignancies.Unfortunately, many BrCa patients exhibit a poor response to immune checkpoint inhibitors (ICIs) because of a deficiency of infiltrating immune cells.Earlier research has shown that guanylatebinding protein 1 (GBP1) can modify the inhibitory properties of inflammatory cytokines on endothelial cell proliferation, immigration, and invasion.Objective: Since the fundamental functions of the GBP family in the cancerimmune cycle is uncertain, according to recent findings, the function of GBPs in BrCa was studied.However, the underlying function of the GBP family in the cancer-immunity cycle is uncertain.We decided to study GBPs' role in BrCa.