BBr<sub>3</sub>-Mediated <i>ortho</i> C–H Borylation of Benzamides
We have developed a BBr<sub>3</sub>-mediated, metal-free <i>ortho</i> C-H borylation of benzamides, enabling the synthesis of a wide range of <i>ortho</i>-borylated benzamides in moderate to good yields. This transformation offers a convenient strategy for accessing functionalized benzamides, which are valuable intermediates in pharmaceuticals, agrochemicals, and fine chemical synthesis.
Authors
- C. Dong (ORCID: https://orcid.org/0000-0003-3259-6323)
- Yijia Xu
- Jingrong Cao
- Hua Zhang (ORCID: https://orcid.org/0000-0002-4960-0838)
- Yixuan Liang (ORCID: https://orcid.org/0009-0009-5591-3716)
- Chengyu Du
Institutions
- Minzu University of China (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1021/acs.orglett.5c00822
- Citations
- 8
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 7.49
Funders
- National Natural Science Foundation of China
- South-Central University for Nationalities