Designing Adaptive User Interfaces for mHealth Applications Targeting Chronic Disease: A User-Centered Approach

Mobile Health (mHealth) applications have demonstrated considerable potential in supporting chronic disease self-management; however, they remain underutilized due to low engagement, limited accessibility, and poor long-term adherence. These issues are particularly prominent among users with chronic disease, whose needs and capabilities vary widely. To address this, Adaptive User Interfaces (AUIs) offer a dynamic solution by tailoring interface features to users’ preferences, health status, and contexts. This article presents a two-stage study to develop and validate actionable AUI design guidelines for mHealth applications. In stage one , an AUI prototype was evaluated through focus groups, interviews, and a standalone survey, revealing key user challenges and preferences. These insights informed the creation of an initial set of guidelines. In stage two , the guidelines were refined based on feedback from 20 end users and evaluated by 43 software practitioners through two surveys. This process resulted in nine finalized guidelines. To assess real-world relevance, a case study of four mHealth applications was conducted, with findings supported by user reviews highlighting the utility of the guidelines in identifying critical adaptation issues. This study offers actionable, evidence-based guidelines that help software practitioners design AUI in mHealth to better support individuals managing chronic diseases.