7aaRGD - a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomas
We demonstrate that combining the blockade of SPP1/integrin signaling with ICIs modifies innate immunity and reinvigorates adaptive antitumor responses, which paves the way to improve immunotherapy outcomes in GBM.
Authors
- Salwador Cyranowski (ORCID: https://orcid.org/0000-0001-9611-531X)
- Szymon Baluszek (ORCID: https://orcid.org/0000-0002-9396-7610)
- Mitrajit Ghosh (ORCID: https://orcid.org/0000-0002-2969-219X)
- Aleksandra Ellert‐Miklaszewska (ORCID: https://orcid.org/0000-0002-7947-5660)
- Yuliana Hovorova (ORCID: https://orcid.org/0000-0002-0934-1851)
- Katarzyna Poleszak (ORCID: https://orcid.org/0000-0002-2081-3530)
- Paulina Pilanc (ORCID: https://orcid.org/0000-0003-3354-439X)
- Adrià-Jaume Roura (ORCID: https://orcid.org/0000-0002-8271-8803)
- Kamil Wojnicki (ORCID: https://orcid.org/0000-0002-1630-4389)
- Julian Swatler (ORCID: https://orcid.org/0000-0001-8710-2808)
- Bożena Kamińska (ORCID: https://orcid.org/0000-0002-2642-4616)
- Maria Pasierbińska (ORCID: https://orcid.org/0000-0001-7595-9775)
- Bartłomiej Gielniewski (ORCID: https://orcid.org/0000-0001-8067-0618)
Institutions
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1186/s13046-025-03393-9
- Citations
- 6
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.75
Funders
- European Molecular Biology Organization
- Narodowe Centrum Nauki
- HORIZON EUROPE Marie Sklodowska-Curie Actions