Photobiomodulation Ameliorates Neuronal Damage in an Amyloid-Beta Induced Rat Model

Photobiomodulation (PBM), as a novel noninvasive therapy, has been extensively employed in neurodegenerative disorder research. However, its mechanism of action in Alzheimer's disease (AD) management remains unclear. In this study, a rat model of AD was constructed by administering amyloid-beta (Aβ) intracerebrally, and the influence of 808 nm phototherapy-mediated PBM on AD was explored. The findings indicated that PBM performed a neuroprotective function by reducing neuronal damage in AD and ameliorating cognitive function, mediated by the suppression of Aβ induced neuroinflammation and neuronal apoptosis. This investigation underscores the critical role of PBM in ameliorating Aβ-induced neuronal damage. It provides a theoretical basis for the advancement of near-infrared light application in neurodegenerative disorders.