Multimodal prognostication of autoimmune encephalitis: an Australian autoimmune encephalitis consortium study
Older age, MRI T2/FLAIR hyperintensity, RSE and first-line immunotherapy failure predicted worse mRS and composite clinical-functional outcome at 12 months, while a diagnosis of anti-LGI1 antibody-mediated encephalitis was associated with favourable outcomes. Our data highlight acute clinical factors predictive of a more severe clinical and functional course at 12 months.
Authors
- Richard Macdonell (ORCID: https://orcid.org/0000-0001-6604-3968)
- Charles Benjamin Malpas (ORCID: https://orcid.org/0000-0003-0534-3718)
- James Broadley (ORCID: https://orcid.org/0000-0002-9988-3944)
- Andrew Duncan (ORCID: https://orcid.org/0000-0002-7817-7637)
- Terence John O'Brien (ORCID: https://orcid.org/0000-0002-7198-8621)
- Laurie McLaughlin
- David Gillis (ORCID: https://orcid.org/0000-0003-3858-6943)
- Udaya Seneviratne (ORCID: https://orcid.org/0000-0003-0182-9702)
- Robb Wesselingh (ORCID: https://orcid.org/0000-0002-5898-3287)
- James Beharry (ORCID: https://orcid.org/0000-0002-4932-954X)
- Tomáš Kalinčík (ORCID: https://orcid.org/0000-0003-3778-1376)
- Ernest Butler (ORCID: https://orcid.org/0000-0003-0551-5671)
- Liora ter Horst
- Mastura Monif (ORCID: https://orcid.org/0000-0001-6404-9768)
- Amy G. Brodtmann (ORCID: https://orcid.org/0000-0001-9466-2862)
- Christina Kazzi (ORCID: https://orcid.org/0000-0001-6737-5489)
- Anneke van der Walt (ORCID: https://orcid.org/0000-0002-4278-7003)
- Nabil Seery (ORCID: https://orcid.org/0000-0001-6446-868X)
- Genevieve Skinner
- Cassie Nesbitt (ORCID: https://orcid.org/0000-0002-5895-3459)
- Tracie Tan
- Stefan Blum (ORCID: https://orcid.org/0000-0002-2702-3742)
- Andrew Swayne (ORCID: https://orcid.org/0000-0002-8041-5593)
- Sarah Griffith (ORCID: https://orcid.org/0000-0002-7087-8703)
- Chin Hong Tan (ORCID: https://orcid.org/0000-0002-0980-9936)
- Bruce Taylor (ORCID: https://orcid.org/0000-0003-2807-0070)
- Todd A. Hardy (ORCID: https://orcid.org/0000-0003-4145-3172)
- Mirasol Forcadela (ORCID: https://orcid.org/0000-0002-3268-4457)
- Wendyl D’Souza (ORCID: https://orcid.org/0000-0002-1750-5131)
- Amy J. Halliday (ORCID: https://orcid.org/0000-0001-6032-4347)
- Paul G. Sanfilippo (ORCID: https://orcid.org/0000-0002-1778-9154)
- Sudarshini Ramanathan (ORCID: https://orcid.org/0000-0002-0294-9768)
- Stephen Reddel (ORCID: https://orcid.org/0000-0002-0169-3350)
- Paul Beech (ORCID: https://orcid.org/0000-0003-3871-3682)
- Tiffany Rushen
- Yang Tran
- Helmut Butzkueven
- Katherine Buzzard
- Noushin Chiniforoush
Institutions
- The University of Sydney (AU)
- Concord Hospital (US)
- Queensland Health (AU)
- The Royal Melbourne Hospital (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- QIMR Berghofer Medical Research Institute (AU)
- Geelong Hospital (AU)
- Concord Repatriation General Hospital (AU)
- Princess Alexandra Hospital (AU)
- Royal Hobart Hospital (AU)
- St Vincent's Hospital Melbourne (AU)
- Monash Alfred Psychiatry Research centre (AU)
- Eastern Health (AU)
- Peninsula Health (AU)
- Monash Health (AU)
- Alfred Health (AU)
- Austin Health (AU)
- Monash University (AU)
- Neuroscience Research Australia (AU)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1007/s00415-025-13069-1
- Citations
- 2
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Monash University
- National Health and Medical Research Council