Decreased plasma visfatin concentrations in pediatric aneurysmal bone cyst: a pilot study

Objective: This is a prospective study and visfatin values of patients with aneurysmal bone cysts (ABC) were compared with those of healthy individuals.Method: This study consists of 20 patients diagnosed with ABC (Group 1) and 30 healthy patients (Group 2).Age, gender, cyst sizes, and visfatin values of all patients were recorded and evaluated.Results: A total of 50 patients, 20 from Group 1 and 30 from Group 2, were included in our study.The mean age was 13.80 3.98 years in Group 1 and 14.67 4.24 years in Group 2, and no statistically significant difference was found between the groups (p > 0.05).While 60% of the patients in Group 1 were male, in Group 2, 53% of the patients were male.Cyst area was recorded as 1171 (512-2310) mm 2 .The visfatin value was 10.70 5.91 ng/mL in Group 1 and 15.23 5.86 ng/mL in Group 2. The visfatin value in the ABC group was found to be statistically significantly lower than the control group (p < 0.05).No correlation was found between cyst area and visfatin (p > 0.05).Conclusion: Our study found that visfatin levels are significantly lower in patients with ABC s compared to healthy controls, suggesting its potential as a diagnostic biomarker.The ROC analysis showed a good diagnostic ability.