First detection of HBV nucleic acid in the lung tissue of a patient with spontaneous recovery from HBV infection by tNGS: a case report
This case study is the first to use tNGS to precisely analyze the bronchoalveolar lavage fluid sample and the transthoracic lung fine needle aspiration sample from different sampling periods. It accurately identifies HBV nucleic acid replication in the lungs of patients with spontaneous HBV - infection recovery, offering new ideas and evidence for HBV research in extra - hepatic tissues.
Authors
- Lanting Zhou (ORCID: https://orcid.org/0000-0003-1427-0485)
- Xiaoxia Yang (ORCID: https://orcid.org/0000-0001-7767-9718)
- Zhenzhen Li (ORCID: https://orcid.org/0000-0002-7035-6657)
- Xiaoqing Dai
- Zhengjiang Cheng
- Huang Shaojun
- Ming Chang (ORCID: https://orcid.org/0009-0006-8356-4195)
- Shui Xiaochuan
Institutions
- Hubei University of Arts and Science (CN)
- Xiangyang Central Hospital (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1186/s12879-025-10997-1
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Hubei University of Arts and Science
- Hubei University