SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound
This study indicates that a novel SHP2-mediated cell death mechanism, paraptosis, plays a role in post-traumatic OA progression. LIPUS helps maintain cartilage-subchondral bone unit integrity by targeting SHP2 inhibition. SHP2 emerges as a potential therapeutic target, while LIPUS provides a promising non-invasive approach for treating trauma-related OA.
Authors
- Fengjing Guo (ORCID: https://orcid.org/0000-0002-5968-4836)
- Xingru Shang
- Xiaofeng Deng (ORCID: https://orcid.org/0000-0002-4531-7760)
- Xiaoxia Hao (ORCID: https://orcid.org/0000-0002-5839-5469)
- Ruimin Chi (ORCID: https://orcid.org/0000-0002-1153-971X)
- Tao Xu (ORCID: https://orcid.org/0000-0003-1622-8985)
- Zehang Zheng
- Jiawei Liu
- Yiwen Zhang (ORCID: https://orcid.org/0000-0002-7304-9820)
- Chunran Pan
- Kai Sun (ORCID: https://orcid.org/0000-0002-1929-0453)
- Wenjie Hou (ORCID: https://orcid.org/0000-0002-3418-2768)
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.jot.2025.04.005
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- National Natural Science Foundation of China