Deoxycholic Acid and Cognitive Impairment and Decline in the Chronic Renal Insufficiency Cohort (CRIC)
Among individuals with CKD stages 2-4, higher DCA levels were independently associated with prevalent cognitive impairment in Category Fluency. The association between DCA and progressive cognitive impairment assessed by 3MS was small and likely not clinically significant.
Authors
- Xuan Cai (ORCID: https://orcid.org/0000-0003-4629-5847)
- Tamara Isakova (ORCID: https://orcid.org/0000-0002-9763-2367)
- Anand Srivastava (ORCID: https://orcid.org/0000-0002-8109-1420)
- Ester Oh (ORCID: https://orcid.org/0000-0003-4942-0762)
- Harold I. Feldman (ORCID: https://orcid.org/0000-0003-4572-2608)
- Kristen L. Nowak (ORCID: https://orcid.org/0000-0001-9364-3256)
- Makoto Miyazaki (ORCID: https://orcid.org/0000-0002-8704-8511)
- Parisa Mortaji
- Manjula Kurella Tamura (ORCID: https://orcid.org/0000-0001-5227-2479)
- Michael J. Fischer (ORCID: https://orcid.org/0009-0001-1713-9741)
- Katherine T. Mills (ORCID: https://orcid.org/0000-0002-4278-5788)
- Rebecca Frazier (ORCID: https://orcid.org/0000-0002-7781-5123)
- Ana Catherine Ricardo (ORCID: https://orcid.org/0000-0001-8670-3644)
- Jiang He (ORCID: https://orcid.org/0000-0002-8286-9652)
- Anna Jovanovich
- Amanda Anderson (ORCID: https://orcid.org/0000-0002-3351-859X)
- Michel Chonchol
- Katherine Wolfrum
Institutions
- Northwestern University (US)
- Tulane University (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- VA Eastern Colorado Health Care System (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Pennsylvania (US)
- Stanford University (US)
Publication Details
- Journal
- Kidney Medicine
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.xkme.2025.101018
- Primary Topic
- Renal function and acid-base balance
- Type
- article
- Field-Weighted Citation Impact
- 0.00