Effects of children's microbiota on adipose and intestinal development in sex-matched mice persist into adulthood following a single fecal microbiota transplantation
Early-life FMT induced long-lasting effects on the metabolic landscape, profoundly affecting adipose tissue function and systemic glucose homeostasis in adulthood. Donor dietary habits correlated with the fecal microbial profiles observed in recipient mice. These findings highlight the critical need for identifying and leveraging beneficial exposures during early development to combat obesity and diabetes.
Authors
- Enzo Nisoli (ORCID: https://orcid.org/0000-0002-6670-1630)
- Mercedes Pardo-Tendero (ORCID: https://orcid.org/0000-0001-8878-8311)
- Assuero Giorgetti (ORCID: https://orcid.org/0000-0001-5016-3826)
- Daniele Panetta (ORCID: https://orcid.org/0000-0002-4184-0175)
- Daniela Campani (ORCID: https://orcid.org/0000-0001-5987-734X)
- Gabriele Conti (ORCID: https://orcid.org/0000-0002-4623-043X)
- Patricia Iozzo (ORCID: https://orcid.org/0000-0001-6443-7074)
- Federica La Rosa (ORCID: https://orcid.org/0000-0003-1671-6057)
- Patrizia Brigidi (ORCID: https://orcid.org/0000-0001-8375-6150)
- Monica Barone (ORCID: https://orcid.org/0000-0001-5229-570X)
- Chiara Ruocco (ORCID: https://orcid.org/0000-0002-6544-2067)
- Daniel Monleón (ORCID: https://orcid.org/0000-0002-4803-1573)
- Silvia Bernardi (ORCID: https://orcid.org/0000-0002-1022-3350)
- Maria Angela Guzzardi
- Daria Riabitch
Institutions
- University of Pisa (IT)
- Istituto di Scienza e Tecnologie dell'Informazione "Alessandro Faedo" (IT)
- University of Milan (IT)
- National Research Council (IT)
- Fondazione Toscana Gabriele Monasterio (IT)
- INCLIVA Health Research Institute (ES)
- Czech Academy of Sciences, Institute of Physiology (CZ)
- University of Bologna (IT)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.molmet.2025.102157
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00