Recapitulation of in vivo angiogenesis and osteogenesis within an ex vivo muscle pouch-based coral-derived macroporous construct organoid model
This study partly elucidated the molecular signaling events involved in the development of an <i>ex vivo</i> tissue-based osteogenic organoid that closely resembled its <i>in vivo</i> counterpart. This would facilitate the development of well vascularized artificial bone grafts for treating segmental bone defects.
Authors
- Jiarun Bai (ORCID: https://orcid.org/0000-0003-3647-5844)
- Tao He (ORCID: https://orcid.org/0000-0002-7017-4503)
- Roland M. Klar
- Chao Zhang (ORCID: https://orcid.org/0000-0001-8118-5251)
- Gen Li (ORCID: https://orcid.org/0000-0002-6862-5547)
- Yugang Wang (ORCID: https://orcid.org/0000-0003-4687-4742)
- Yuqi Dong
Institutions
- Shanghai Jiao Tong University (CN)
- University of the Witwatersrand (ZA)
- Renji Hospital (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.jot.2025.04.002
- Citations
- 2
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China
- National University's Basic Research Foundation of China
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- National Key Research and Development Program of China Stem Cell and Translational Research