An Atypical Presentation of Post-herpetic Neuralgia and Bell’s Palsy in a Diabetic Patient: A Case Report

Post-herpetic neuralgia (PHN) is a severe and often persistent complication of varicella-zoster virus (VZV) reactivation, particularly affecting the elderly and immunocompromised. We present the case of a 54-year-old male with a history of childhood chickenpox and type 2 diabetes mellitus who developed PHN following VZV reactivation. Initial symptoms of burning and painful paresthesia in the shoulders, combined with the subsequent onset of Bell's palsy, confirmed the diagnosis of PHN. Beginning with an initial treatment of gabapentin, significant relief was ultimately achieved with valacyclovir, emphasizing the importance of early and targeted intervention in PHN management. This case underscores the complexities of diagnosing PHN, especially in the presence of comorbidities, and highlights the need for further research to refine treatment strategies for this debilitating condition.

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Journal
Cureus
Published
2025-04-25
DOI
https://doi.org/10.7759/cureus.83014
Primary Topic
Peripheral Neuropathies and Disorders
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article
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article

An Atypical Presentation of Post-herpetic Neuralgia and Bell’s Palsy in a Diabetic Patient: A Case Report

Osman Mahboob, Yusuf Amawi, Cynthia Tie, John S Acosta-Peñaloza et al.
Cureus
Peripheral Neuropathies and Disorders
article

An Atypical Presentation of Post-herpetic Neuralgia and Bell’s Palsy in a Diabetic Patient: A Case Report

Osman Mahboob, Yusuf Amawi, Cynthia Tie, John S Acosta-Peñaloza, Natalia Kabat
article en

Abstract

Post-herpetic neuralgia (PHN) is a severe and often persistent complication of varicella-zoster virus (VZV) reactivation, particularly affecting the elderly and immunocompromised. We present the case of a 54-year-old male with a history of childhood chickenpox and type 2 diabetes mellitus who developed PHN following VZV reactivation. Initial symptoms of burning and painful paresthesia in the shoulders, combined with the subsequent onset of Bell's palsy, confirmed the diagnosis of PHN. Beginning with an initial treatment of gabapentin, significant relief was ultimately achieved with valacyclovir, emphasizing the importance of early and targeted intervention in PHN management. This case underscores the complexities of diagnosing PHN, especially in the presence of comorbidities, and highlights the need for further research to refine treatment strategies for this debilitating condition.

CureusVol. 17(4)
Florida State University (US)
Gender equality
Openalex Percentile: Top 85%
Peripheral Neuropathies and Disorders
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An Atypical Presentation of Post-herpetic Neuralgia and Bell’s Palsy in a Diabetic Patient: A Case Report — Osman Mahboob, Yusuf Amawi, et al. · Cureus (2025) | TGRS Research Map | TGRS