LGR5 interacts with HSP90AB1 to mediate enzalutamide resistance by activating the WNT/β-catenin/AR axis in prostate cancer
LGR5 directly binds to HSP90AB1 and mediates GSK-3β phosphorylation, promoting AR expression by regulating the WNT/β-catenin signaling pathway, thereby conferring resistance to enzalutamide treatment in prostate cancer.
Authors
- Hai Huang (ORCID: https://orcid.org/0000-0002-8147-0826)
- Kaixuan Guo (ORCID: https://orcid.org/0000-0003-2372-4901)
- Yiran Tao (ORCID: https://orcid.org/0000-0002-8894-5943)
- Qiong Wang (ORCID: https://orcid.org/0000-0003-2564-7778)
- Ze Gao
- Kewei Xu (ORCID: https://orcid.org/0000-0003-4649-4619)
- Zhi Xiong (ORCID: https://orcid.org/0000-0002-8709-6150)
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Nanfang Hospital (CN)
- Guangzhou First People's Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1097/cm9.0000000000003538
- Citations
- 2
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04