Effectiveness of the Bedaquiline, Pretomanid, and Linezolid Regimen, With or Without Moxifloxacin, for Drug-Resistant Tuberculosis in Ukraine Under Programmatic Conditions
Bedaquiline, pretomanid, and linezolid, with or without moxifloxacin, have revolutionized treatment for drug-resistant tuberculosis. In Ukraine, we observed an 86% success rate (394 of 460) under programmatic conditions when drugs were accessible, exceeding prior estimates (58%) and aligning with trial findings (80%-90%). However, access and implementation remain a concern in conflict-affected settings.
Authors
- Olha Siomak
- Vitaly Stephanovich Didyk
- Tetiana Butova (ORCID: https://orcid.org/0000-0001-6587-222X)
- Dmytro Butov (ORCID: https://orcid.org/0000-0002-8792-901X)
- V.V. Hlynenko
- Victor Næstholt Dahl (ORCID: https://orcid.org/0000-0003-2965-6348)
- Vitalii Vekshyn (ORCID: https://orcid.org/0000-0003-2834-8773)
- A.V. Fedorec (ORCID: https://orcid.org/0000-0003-0994-5265)
- A. Ye. Bogomolov (ORCID: https://orcid.org/0000-0002-5336-4858)
- О. М. Raznatovska (ORCID: https://orcid.org/0000-0003-2252-9063)
- L. A. Hryshchuk (ORCID: https://orcid.org/0000-0002-2528-8843)
- Iryna Makoida (ORCID: https://orcid.org/0000-0002-8258-2643)
- S. І. Kornaha (ORCID: https://orcid.org/0000-0002-6622-0503)
- Мykola Ostrovskyy (ORCID: https://orcid.org/0000-0002-3922-0583)
- Mykhailo Kuzhko (ORCID: https://orcid.org/0000-0001-6730-9238)
- Nataliia Chursina
- Lyubov Markovtsiy
- Vasyl Skryp
- Ole Skouvig Pedersen (ORCID: https://orcid.org/0009-0002-7338-1433)
- Y SHPAK
- Natalia Kondratyuk
- Tetiana Klymenko
- Daria Yankovska (ORCID: https://orcid.org/0009-0002-2538-4867)
- Daria Levandovska
- Nataliia Yevsiukova
Institutions
- Ivano-Frankivsk National Medical University (UA)
- National University Zaporizhzhia Polytechnic (UA)
- Sumy State University (UA)
- Aarhus University Hospital (DK)
- Zaporizhzhia State Medical and Pharmaceutical University (UA)
- Lesya Ukrainka Volyn National University (UA)
- Polissia National University (UA)
- Consultative and Diagnostic Center (RU)
- Cherkasy State Technological University (UA)
- National Pirogov Memorial Medical University, Vinnytsya (UA)
- National Academy of Medical Sciences of Ukraine (UA)
- Saint-Petersburg Research Institute of Phthisiopulmonology (RU)
- I.Horbachevsky Ternopil National Medical University (UA)
- Kharkiv National Medical University (UA)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1093/cid/ciaf214
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40