Plasma C4d levels correlate with treatment response and renal activity in proliferative lupus nephritis
All complement markers were affected by immunosuppressive therapy and associated with response to therapy. Levels of C4d and C4d/C4 at follow-up biopsies showed a strong association with both clinical and histopathological response in PLN. The correlation with elevated C4d and C4d/C4 and persisting high activity index on repeated biopsies strengthens the findings on C4d as a promising biomarker for treatment response in PLN. The C4 genetic variations did not influence C4 levels or response to treatment.
Authors
- Sepehr Sarrafzadeh Zargar
- Lina-Marcela Díaz-Gallo (ORCID: https://orcid.org/0000-0002-5688-0102)
- Agneta Zickert (ORCID: https://orcid.org/0000-0001-9843-3127)
- Iva Gunnarsson (ORCID: https://orcid.org/0000-0002-4514-7706)
- Ann Mongan
- Henk‐André Kroon
- Myriam Martin (ORCID: https://orcid.org/0000-0003-1526-8678)
- Anna Juto
- Caroline Grönwall (ORCID: https://orcid.org/0000-0002-9111-5537)
- Anna Marie Blom (ORCID: https://orcid.org/0000-0002-1348-1734)
- Edmund Chang
Institutions
- Karolinska University Hospital (SE)
- Lund University (SE)
- Annexon Biosciences (United States) (US)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1093/rheumatology/keaf160
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Reumatikerförbundet