Extracellular matrix mechanical cues (dys)regulate metabolic redox homeostasis due to impaired autophagic flux
These findings emphasize the critical role of ECM stiffness in regulating neuronal cell metabolism and suggest that prolonged exposure to soft ECM may mimic key aspects of neurodegenerative disease pathology, thereby enhancing the physiological relevance of in vitro models. This study underscores the necessity for further research into ECM mechanics as a contributing factor in neurodegenerative disease progression and as a potential target for therapeutic strategies.
Authors
- Mário Grãos
- Cláudia Cavadas (ORCID: https://orcid.org/0000-0001-8020-9266)
- Tânia Lourenço (ORCID: https://orcid.org/0000-0003-1198-8117)
- Manuela Ferreira (ORCID: https://orcid.org/0000-0001-9498-8061)
- Célia A. Aveleira (ORCID: https://orcid.org/0000-0002-2191-0682)
- Heloísa Gerardo (ORCID: https://orcid.org/0000-0003-1492-1882)
- José Teixeira (ORCID: https://orcid.org/0000-0003-0834-5698)
- Susana M. N. Simões (ORCID: https://orcid.org/0000-0003-3924-0936)
- Júlio Torres (ORCID: https://orcid.org/0000-0001-6686-2832)
- Lino Ferreira (ORCID: https://orcid.org/0000-0001-8985-9302)
- Paulo J. Oliveira (ORCID: https://orcid.org/0000-0002-5201-9948)
Institutions
- University of Coimbra (PT)
Publication Details
- Journal
- European Journal of Clinical Investigation
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1111/eci.70051
- Citations
- 2
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Fundação para a Ciência e a Tecnologia
- HORIZON EUROPE Health