Clinical features of Rathke’s cleft cyst with secondary hypophysitis and outcomes of endoscopic transnasal surgery versus features of common Rathke’s cleft cysts: a single-center retrospective cohort study

RCC with secondary hypophysitis was associated with a high incidence of headache, fever, panhypopituitarism, and diabetes insipidus. The reaccumulation rate and time to reaccumulation in the RCC with secondary hypophysitis group did not differ from those in the common RCC group; however, the operative rate at reaccumulation was extremely high for those with RCC with secondary hypophysitis, indicating the need for tailored management strategies. Future studies with larger sample sizes and refined criteria are essential to better understanding RCCs with secondary hypophysitis and to optimize therapeutic interventions.