Clinical phenotypes of Alzheimer’s disease: investigating atrophy patterns and their pathological correlates
For both clinical phenotypes, cortical volume is affected by Aβ and neuro-axonal damage, but in opposing directions. Differences in volume-pathology relationships between clinical phenotypes are region-specific. The findings of this study could improve the interpretation of MRI datasets in heterogenous AD cohorts, both in research and clinical settings.
Authors
- Annemieke J.M. Rozemüller (ORCID: https://orcid.org/0000-0003-2528-4428)
- Laura E. Jonkman (ORCID: https://orcid.org/0000-0003-1479-3649)
- Isabella M. Frigerio (ORCID: https://orcid.org/0000-0002-7616-4226)
- Jeroen J.M. Hoozemans (ORCID: https://orcid.org/0000-0002-2888-8967)
- Elizabeth Gordón (ORCID: https://orcid.org/0000-0001-5935-2463)
- Niels Reijner
- Femke H. Bouwman (ORCID: https://orcid.org/0000-0002-0527-2270)
- Thomas Jubault
- Baayla D.C. Boon (ORCID: https://orcid.org/0000-0002-4922-3286)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Wilma D. J. van de Berg (ORCID: https://orcid.org/0000-0002-6175-5357)
- Nicolas Guizard (ORCID: https://orcid.org/0000-0003-2660-5123)
- Maud M.A. Bouwman (ORCID: https://orcid.org/0000-0002-9481-0332)
Institutions
- Netherlands Institute for Neuroscience (NL)
- Jacksonville College (US)
- Amsterdam Neuroscience (NL)
- Mayo Clinic in Florida (US)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1186/s13195-025-01727-5
- Citations
- 4
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 5.44
Funders
- Health~Holland
- Amsterdam University Medical Centers