Building a pre-surgical multiparametric-MRI-based morphologic, qualitative, semiquantitative, first and high-order radiomic predictive treatment response model for undifferentiated pleomorphic sarcoma to replace RECIST
Mp-MRI-derived features are valuable in assessing UPS treatment response. A pre-operative model that combines PWI/DCE TIC-type II, PWI/DCE Capsular pattern, and CE-SWI Complete Ring pattern can reliably predict successfully treated UPS with > = 90% PATE, outperforming RECIST, which was proven unreliable in separating responders from partial/non-responders. Institutions that have not yet implemented CE-SWI can rely on a single-sequence approach based on PWI/DCE, combining the presence of TIC II and Capsular enhancement as criteria for response prediction.
Authors
- Andrew Justin Bishop (ORCID: https://orcid.org/0000-0002-7737-8023)
- Ravin Ratan (ORCID: https://orcid.org/0000-0002-4914-7922)
- Ken‐Pin Hwang (ORCID: https://orcid.org/0000-0002-8196-3794)
- Chengyue Wu (ORCID: https://orcid.org/0000-0002-3789-404X)
- Dejka M. Araujo (ORCID: https://orcid.org/0000-0002-1223-6542)
- R. Jason Stafford (ORCID: https://orcid.org/0000-0003-4091-8417)
- John E. Madewell (ORCID: https://orcid.org/0000-0001-8543-7188)
- Mathew Antony
- Elvis Duran-Sierra (ORCID: https://orcid.org/0000-0003-0077-8499)
- J. Espinoza (ORCID: https://orcid.org/0009-0002-8505-216X)
- Robert S. Benjamin (ORCID: https://orcid.org/0000-0002-2589-5870)
- Simon S. Lo (ORCID: https://orcid.org/0000-0002-3744-4065)
- Keila E. Torres (ORCID: https://orcid.org/0000-0002-1855-0989)
- Behrang Amini (ORCID: https://orcid.org/0000-0002-4962-3466)
- Wei‐Lien Wang (ORCID: https://orcid.org/0000-0001-8809-4424)
- William A. Murphy (ORCID: https://orcid.org/0000-0002-7333-2642)
- Jingfei Ma (ORCID: https://orcid.org/0000-0003-2827-8891)
- Pía V. Valenzuela
- Raul F. Valenzuela (ORCID: https://orcid.org/0000-0002-2597-8537)
- Colleen M. Costelloe
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Texas A&M University (US)
Publication Details
- Journal
- Cancer Imaging
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1186/s40644-025-00873-1
- Citations
- 4
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.07