Predictors of platelet count response following intravenous immunoglobulin use for maternal thrombocytopenia
IVIG effectively increases PLT counts in pregnant persons with severe thrombocytopenia, especially in those with a nadir PLT < 30 × 10<sup>9</sup>/L, IPF < 16 %, or pre-IVIG PLT < 50 × 10<sup>9</sup>/L. This study highlights the importance of careful patient selection for IVIG to enhance outcomes and conserve resources. Future research should focus on prospective studies to refine treatment guidelines and resource stewardship of IVIG for maternal thrombocytopenia.
Authors
- Melanie Tokessy
- Roy Khalifé (ORCID: https://orcid.org/0000-0002-3401-4086)
- Alan Karovitch
- Johnathan Mack (ORCID: https://orcid.org/0000-0002-8304-1953)
- Darine El‐Chaâr (ORCID: https://orcid.org/0000-0002-8266-0242)
- Bonnie Niu (ORCID: https://orcid.org/0000-0002-9295-2564)
- Iris Perelman (ORCID: https://orcid.org/0000-0001-9008-5375)
- Dean Fergusson (ORCID: https://orcid.org/0000-0002-3389-2485)
- Alan Tinmouth (ORCID: https://orcid.org/0000-0001-8869-389X)
- Kathryn E. Webert (ORCID: https://orcid.org/0000-0003-1689-3344)
Institutions
- University of Ottawa (CA)
- Ottawa Hospital (CA)
- Canadian Electricity Association (CA)
- Ottawa Hospital Research Institute (CA)
- Canadian Blood Services (CA)
Publication Details
- Journal
- Transfusion and Apheresis Science
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.transci.2025.104125
- Citations
- 1
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Canadian Blood Services