Expansion microscopy allows quantitative characterization of structural organization of platelet aggregates
Together, these data provide a workflow to qualitatively and quantitatively describe the architecture of platelet aggregates at a range of scales (whole aggregates down to subcellular features within individual platelets). This provides an important tool for analysis of platelet aggregates and thrombi in conditions such as hemostasis, immunothrombosis, and cardiovascular disease.
Authors
- Steven G. Thomas (ORCID: https://orcid.org/0000-0001-8733-7842)
- Robert K. Neely (ORCID: https://orcid.org/0000-0002-5023-8960)
- Jeremy A. Pike (ORCID: https://orcid.org/0000-0003-4163-0335)
- Natalie S. Poulter (ORCID: https://orcid.org/0000-0002-3187-2130)
- Iain B. Styles (ORCID: https://orcid.org/0000-0002-6755-0299)
- Emma L. Faulkner (ORCID: https://orcid.org/0000-0002-2728-7617)
- Evelyn Garlick (ORCID: https://orcid.org/0000-0002-9292-1354)
- Steve P. Watson (ORCID: https://orcid.org/0000-0002-7846-7423)
Institutions
- Queen's University Belfast (GB)
- Birmingham City University (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.jtha.2025.04.014
- Citations
- 1
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- University of Birmingham
- Birmingham Biomedical Research Centre