Therapeutic effect of edaravone on osteoarthritis: targeting NRF2 signaling and mitochondrial function
As a clinically licensed drug used for the treatment of neurological disorders, edaravone has shown promising therapeutic effects on OA development. Mechanistically, edaravone stabilized mitochondrial function and maintained redox homeostasis by activating NRF2 signaling pathway. The protective effects of edaravone against OA were verified <i>in vivo</i> and <i>in vitro</i>. These findings presented robust evidence for repurposing edaravone for the treatment of OA in clinic.
Authors
- Xinyu Wu (ORCID: https://orcid.org/0000-0002-1117-5098)
- Zhangfu Wang (ORCID: https://orcid.org/0000-0001-6592-5213)
- Jiajing Ye
- Jiangjie Chen (ORCID: https://orcid.org/0000-0002-2613-0386)
- Yiyu Chen (ORCID: https://orcid.org/0000-0002-8671-1406)
- Fang Tang (ORCID: https://orcid.org/0000-0001-5070-2922)
- Yuxuan Bao (ORCID: https://orcid.org/0000-0001-5660-6077)
- Zhiyu Fang
- Jingyao Chen (ORCID: https://orcid.org/0000-0002-0749-2656)
- Chao Jiang
- Yuhang Gong
Institutions
- Wenzhou Medical University (CN)
- Zhejiang Taizhou Hospital (CN)
- Zhejiang University (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.jot.2025.04.008
- Citations
- 6
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 10.01
Funders
- Science and Technology Plan Project of Taizhou
- Basic Public Welfare Research Program of Zhejiang Province