Comparison of Al18F-NOTA-FAPI-74 and 18F-FDG PET/CT in the Evaluation and Staging of Hepatobiliary Malignancies
In patients with hepatobiliary malignancies, Al 18 F-NOTA-FAPI-74 PET/CT outperformed 18 F-FDG PET/CT in detecting primary tumors and metastatic lesions, resulting in more accurate staging or restaging. In addition, Al 18 F-NOTA-FAPI-74 PET/CT showed good detection efficacy for tumor-related obstructive inflammation, which was only found in cholangiocarcinoma, thus rendering Al 18 F-NOTA-FAPI-74 the potential to differentiate ICC from hepatocellular carcinoma.
Authors
- B. Chen (ORCID: https://orcid.org/0000-0001-9158-8433)
- Jingjing Zhang (ORCID: https://orcid.org/0000-0002-6948-1813)
- Zhen Huang (ORCID: https://orcid.org/0000-0002-6320-548X)
- Guozhu Hou
- Rong Zheng (ORCID: https://orcid.org/0000-0003-1213-7242)
- Hong Zhao (ORCID: https://orcid.org/0000-0002-7820-0171)
- Zhuo Li (ORCID: https://orcid.org/0000-0001-7775-2831)
- Xiaoyuan Shawn Chen (ORCID: https://orcid.org/0000-0002-9622-0870)
- Aiping Zhou (ORCID: https://orcid.org/0000-0003-1632-837X)
- Xin Cheng (ORCID: https://orcid.org/0000-0001-8619-4878)
- Yuanyuan Jiang (ORCID: https://orcid.org/0000-0002-7438-4081)
- Yi Yang (ORCID: https://orcid.org/0009-0008-0117-8181)
- Xuejuan Wang
Institutions
- National University of Singapore (SG)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Theranostics (New Zealand) (NZ)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1097/rlu.0000000000005889
- Citations
- 3
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- National University of Singapore