68Ga FAPI-04 PET/MRI for Detecting Metastatic Bone Lesions of Esophageal Cancer in Patients With G-CSF Administration, Missed by 18F FDG PET/CT

We report a patient who underwent surgery for esophageal cancer, in whom 18 F FDG PET/CT showed diffuse skeletal uptake, while 68 Ga FAPI-04 PET/MRI revealed significantly higher uptake in bone metastatic lesions. Bone lesions were visible after granulocyte-colony stimulating factor(G-CSF) administration due to lower 68 Ga FAPI-04 background uptake, suggesting its superior potential for detecting bone metastases in esophageal cancer patients after G-CSF treatment.

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Journal
Clinical Nuclear Medicine
Published
2025-04-24
DOI
https://doi.org/10.1097/rlu.0000000000005885
Primary Topic
Peptidase Inhibition and Analysis
Type
article
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0.00
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article

68Ga FAPI-04 PET/MRI for Detecting Metastatic Bone Lesions of Esophageal Cancer in Patients With G-CSF Administration, Missed by 18F FDG PET/CT

Alei Xu, Hui Wang, Xiaoyu Su, Lei Yao et al.
Clinical Nuclear Medicine
Peptidase Inhibition and Analysis
article

68Ga FAPI-04 PET/MRI for Detecting Metastatic Bone Lesions of Esophageal Cancer in Patients With G-CSF Administration, Missed by 18F FDG PET/CT

Alei Xu, Hui Wang, Xiaoyu Su, Lei Yao, Jingxuan Miao
article en

Abstract

We report a patient who underwent surgery for esophageal cancer, in whom 18 F FDG PET/CT showed diffuse skeletal uptake, while 68 Ga FAPI-04 PET/MRI revealed significantly higher uptake in bone metastatic lesions. Bone lesions were visible after granulocyte-colony stimulating factor(G-CSF) administration due to lower 68 Ga FAPI-04 background uptake, suggesting its superior potential for detecting bone metastases in esophageal cancer patients after G-CSF treatment.

Clinical Nuclear MedicineVol. 50(9)
Anhui Medical University (CN), First Affiliated Hospital of Anhui Medical University (CN), Lu'an First People's Hospital (CN)
Good health and well-being
Openalex Percentile: Top 87%
Peptidase Inhibition and Analysis
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68Ga FAPI-04 PET/MRI for Detecting Metastatic Bone Lesions of Esophageal Cancer in Patients With G-CSF Administration, Missed by 18F FDG PET/CT — Alei Xu, Hui Wang, et al. · Clinical Nuclear Medicine (2025) | TGRS Research Map | TGRS