Phase II Study of Pexidartinib Plus Sirolimus in Unresectable Malignant Peripheral Nerve Sheath Tumors Identifies M2 Macrophage Activation
Further studies of combination of pexidartinib and sirolimus and/or immunotherapy should be performed in the subset of patients with advanced MPNST with an immune-rich TME.
Authors
- Liner Ge (ORCID: https://orcid.org/0000-0001-8259-3871)
- Brian Andrew Van Tine (ORCID: https://orcid.org/0000-0003-4572-6668)
- Gary K. Schwartz (ORCID: https://orcid.org/0000-0003-1813-5061)
- Rashmi K Chugh (ORCID: https://orcid.org/0000-0002-4633-6971)
- Aik Choon Tan (ORCID: https://orcid.org/0000-0003-2955-8369)
- John S.A. Chrisinger (ORCID: https://orcid.org/0000-0002-7138-0923)
- Gulam A. Manji (ORCID: https://orcid.org/0000-0001-9817-2414)
- Naomi Sender (ORCID: https://orcid.org/0000-0002-5295-0329)
- Shiny Titus (ORCID: https://orcid.org/0000-0002-8391-825X)
- Shing Mirn Lee (ORCID: https://orcid.org/0000-0001-8413-6869)
- Angela C. Hirbe (ORCID: https://orcid.org/0000-0003-1719-0771)
- Michael May (ORCID: https://orcid.org/0000-0002-6187-4655)
- L. Stanton (ORCID: https://orcid.org/0000-0001-7070-7544)
- Sarah Sta Ana (ORCID: https://orcid.org/0000-0003-1572-1487)
- Peter A. Sims (ORCID: https://orcid.org/0000-0002-3921-4837)
- Varun Monga (ORCID: https://orcid.org/0000-0002-1185-5448)
- Yang Lyu (ORCID: https://orcid.org/0000-0002-4353-0082)
- Brian Labadie (ORCID: https://orcid.org/0000-0002-3648-4663)
- Mohammed Milhem (ORCID: https://orcid.org/0000-0003-4663-6824)
Institutions
- University of Iowa (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- University of Utah (US)
- University of Michigan (US)
- Columbia University Irving Medical Center (US)
- Huntsman Cancer Institute (US)
- Michigan Center for Translational Pathology (US)
- Case Comprehensive Cancer Center
- Columbia University (US)
Publication Details
- Journal
- JCO oncology advances.
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1200/oa-24-00083
- Citations
- 4
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 5.56