Phase II Study of Pexidartinib Plus Sirolimus in Unresectable Malignant Peripheral Nerve Sheath Tumors Identifies M2 Macrophage Activation

Further studies of combination of pexidartinib and sirolimus and/or immunotherapy should be performed in the subset of patients with advanced MPNST with an immune-rich TME.

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Publication Details

Journal
JCO oncology advances.
Published
2025-03-01
DOI
https://doi.org/10.1200/oa-24-00083
Citations
4
Primary Topic
Neurofibromatosis and Schwannoma Cases
Type
article
Field-Weighted Citation Impact
5.56
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article

Phase II Study of Pexidartinib Plus Sirolimus in Unresectable Malignant Peripheral Nerve Sheath Tumors Identifies M2 Macrophage Activation

Liner Ge, Brian Andrew Van Tine, Gary K. Schwartz, Rashmi K Chugh et al.
4 citations
JCO oncology advances.
Neurofibromatosis and Schwannoma Cases
5.56
article

Phase II Study of Pexidartinib Plus Sirolimus in Unresectable Malignant Peripheral Nerve Sheath Tumors Identifies M2 Macrophage Activation

Liner Ge, Brian Andrew Van Tine, Gary K. Schwartz, Rashmi K Chugh, Aik Choon Tan, John S.A. Chrisinger, Gulam A. Manji, Naomi Sender, Shiny Titus, Shing Mirn Lee, Angela C. Hirbe, Michael May, L. Stanton, Sarah Sta Ana, Peter A. Sims, Varun Monga, Yang Lyu, Brian Labadie, Mohammed Milhem
article en
4 citations

Abstract

Further studies of combination of pexidartinib and sirolimus and/or immunotherapy should be performed in the subset of patients with advanced MPNST with an immune-rich TME.

JCO oncology advances.Vol. 2(2)
University of Iowa (US), University of California, San Francisco (US), Washington University in St. Louis (US), University of Utah (US), University of Michigan (US), Columbia University Irving Medical Center (US), Huntsman Cancer Institute (US), Michigan Center for Translational Pathology (US), Case Comprehensive Cancer Center, Columbia University (US)
Openalex Percentile: Top 4%
Neurofibromatosis and Schwannoma Cases
5.56
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