The Roxadustat (FG-4592) ameliorates tubulointerstitial fibrosis by promoting intact FGF23 cleavage
FG-4592 attenuates TIF through Furin-mediated proteolytic cleavage of iFGF23. These findings provide novel mechanistic insights into HIF-PHI-mediated renal protection and establish a theoretical framework for clinical translation.
Authors
- Zhong-Tang Li
- Zuo‐Lin Li (ORCID: https://orcid.org/0000-0002-6694-8406)
- Yan Tu (ORCID: https://orcid.org/0000-0001-7955-8485)
- Xiaowen Hu (ORCID: https://orcid.org/0000-0002-4295-0747)
- Bi‐Cheng Liu (ORCID: https://orcid.org/0000-0002-4584-1853)
- Hong Shu Liu (ORCID: https://orcid.org/0000-0003-3685-6268)
- Jingjing Zhu (ORCID: https://orcid.org/0000-0002-9905-2972)
- Yan Zhou (ORCID: https://orcid.org/0000-0001-9352-7108)
- Jing Wang (ORCID: https://orcid.org/0000-0002-3715-1174)
Institutions
- Zhongda Hospital Southeast University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1186/s12964-025-02175-2
- Citations
- 4
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.72
Funders
- Natural Science Foundation of Jiangsu Province
- Fundamental Research Funds for the Central Universities