Application value of opioid-free anesthesia in renal cyst decompression by laparoscopy

Objective:The objective of the study was to analyze the application value of opioid-free anesthesia (OFA) in renal cyst decompression by laparoscopy.Method: A total of 124 patients undergoing renal cyst decompression by laparoscopy in our hospital were selected and divided into opioid anesthesia (OA) and OFA groups (n = 62).Fentanyl and remifentanil were used for anesthesia induction in the OA group, while lidocaine and dexmedetomidine were employed for anesthesia induction in the OFA group. The homeostasis indicators (cortisol [Cor], adrenocorticotropic hormone [ACTH], C-reactive protein [CRP], and interleukin-6 [IL-6])were also compared 10 min before anesthesia (T a ), at the end of operation (T b ), and 24 h after operation (T c ). Results: At T 1 -T 3 , heart rate, mean arterial pressure, mean airway pressure, and partial pressure of end-tidal carbon dioxide were all lower in OFA group than those in OA group (p < 0.05).At T b -T c , the levels of Cor, ACTH, CRP, and IL-6 were all higher in both groups than those at T a (p < 0.05), while they were lower in OFA group than those in OA group (p < 0.05).Conclusion: OFA is more beneficial to the respiratory and circulatory system and homeostasis of patients, and has higher anesthetic safety.