Ezetimibe plus statin combination versus double-dose statin in patients with dyslipidemia and atherosclerotic cardiovascular disease risk: a comprehensive systematic review and meta-analysis of 47 randomized controlled trials
Ezetimibe plus statin therapy demonstrated superior lipid-lowering efficacy compared with double-dose statin therapy, with no additional clinical benefit. There was no difference in overall adverse events. There was a higher incidence of severe adverse events with combination therapy compared to double-dose statin therapy, although these events were rare and not believed to be attributable to medication.
Authors
- Yasmine Adel Mohammed (ORCID: https://orcid.org/0000-0001-8359-0824)
- Salem Elshenawy (ORCID: https://orcid.org/0000-0001-8164-4358)
- Yazan Al-Mohtasib (ORCID: https://orcid.org/0009-0007-4331-9045)
- Abdelrahman Mahmoud (ORCID: https://orcid.org/0000-0001-7514-1623)
- Basel Abdelazeem (ORCID: https://orcid.org/0000-0002-2919-6196)
- Hazem Mohamed Salamah (ORCID: https://orcid.org/0000-0002-2291-8862)
- Majd M. AlBarakat (ORCID: https://orcid.org/0000-0002-4676-8942)
- Ahmed Mazen Amin (ORCID: https://orcid.org/0009-0006-2687-3880)
- Omar Ahmed Abdelwahab (ORCID: https://orcid.org/0000-0001-8266-0245)
- Husam Abu Suilik (ORCID: https://orcid.org/0000-0002-2807-3725)
- Hazem Rezq (ORCID: https://orcid.org/0000-0002-8871-6921)
- Ahmed A. Ibrahim (ORCID: https://orcid.org/0000-0003-3669-5724)
- Ali Ashraf Salah Ahmed (ORCID: https://orcid.org/0000-0003-3870-5148)
- Mohamed R. Abdelraouf (ORCID: https://orcid.org/0009-0001-8261-9637)
Institutions
- West Virginia University (US)
- Jordan University of Science and Technology (JO)
- Hashemite University (JO)
- Mansoura University (EG)
- Zagazig University (EG)
- Al-Azhar University (ID)
- Menoufia University (EG)
- University of Missouri–Kansas City (US)
- Alexandria University (EG)
- Minia University (EG)
- Assiut University (EG)
Publication Details
- Journal
- Baylor University Medical Center Proceedings
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1080/08998280.2025.2487966
- Citations
- 2
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 4.01