CuF<sub>2</sub>/DTBP-Catalyzed Chan-Lam Coupling of Oxazolidinones with Arylboronic Acid Pinacol Ester: Scope and Application
A new combination of CuF<sub>2</sub>/DTBP-catalyzed <i>N</i>-arylation of oxazolidinones, amides, amines, and azoles has been explored with arylboronic acid pinacol esters (arylBpin). This methodology has also been applied to the synthesis of oxazolidinone-based marketed drugs, including Rivaroxaban, Linezolid, Sutezolid, and Toloxatone. Mechanistic investigations using various spectroscopic techniques and DFT studies revealed the role of DTBP/MeOH in the catalytic process.
Authors
- Krishanu Mondal (ORCID: https://orcid.org/0009-0003-0207-3617)
- Parthasarathi Das (ORCID: https://orcid.org/0000-0002-9306-4956)
- Arunava Sengupta (ORCID: https://orcid.org/0000-0001-6936-5938)
- Tanumay Roy
- Pallabi Halder (ORCID: https://orcid.org/0009-0004-9257-4323)
Institutions
- Indian Institute of Technology Dhanbad (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1021/acs.joc.5c00283
- Citations
- 6
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 4.74
Funders
- Indian Institute of Technology (Indian School of Mines), Dhanbad
- Science and Engineering Research Board
- Board of Research in Nuclear Sciences