Lower Expression of SARS-CoV-2 Host Cell Entry Genes in the Intestinal Mucosa of IBD Patients With Quiescent or Mildly Active Disease
Overall, our study indicates that the presence of higher basal circulating levels of MBL in CD patients and the decreased intestinal mucosa expression of the SARS-CoV-2 receptor ACE2 and the host cell priming proteases TMPRSS2 and TMPRSS4 in both CD and UC patients may reduce COVID-19 risk, underscoring the potential protective role of these biomarkers in IBD populations against SARS-CoV-2 infection.
Authors
- Gabriela A. N. Crespi
- Laura Francesca Pisani (ORCID: https://orcid.org/0000-0002-9490-3723)
- Chiara Porta (ORCID: https://orcid.org/0000-0002-7183-5561)
- Guglielmo Albertini Petroni (ORCID: https://orcid.org/0000-0001-5015-0347)
- Flavio Caprioli (ORCID: https://orcid.org/0000-0002-8077-8175)
- Luca Pastorelli (ORCID: https://orcid.org/0000-0002-2810-9951)
- Silvia Mola (ORCID: https://orcid.org/0000-0003-4517-9051)
- Maria Laura Annunziata (ORCID: https://orcid.org/0000-0002-1012-4117)
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- AOL (United States) (US)
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Centro Cardiologico Monzino (IT)
- IRCCS Policlinico San Donato (IT)
- Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1093/ibd/izaf079
- Citations
- 4
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Fondazione Umberto Veronesi