scRNA-seq reveals that VEGF signaling mediates the response to neoadjuvant anlotinib combined with PD-1 blockade therapy in non-small cell lung cancer
In conclusion, VEGF signaling dependent dynamic changes in endothelial and epithelial cells are deeply involved in the formation of anlotinib resistance and immunosuppression phenotypes in NSCLC patients.
Authors
- Lili Yang (ORCID: https://orcid.org/0000-0003-4274-4617)
- Baihui Li (ORCID: https://orcid.org/0009-0004-7660-0480)
- Haixia Jin (ORCID: https://orcid.org/0000-0003-0116-9070)
- Meng Wang (ORCID: https://orcid.org/0000-0002-1573-0255)
- Qinfen Zhang (ORCID: https://orcid.org/0000-0001-6599-8105)
- Qiyu Wang (ORCID: https://orcid.org/0000-0003-4959-7437)
- Ziqi Huang (ORCID: https://orcid.org/0000-0003-2771-5957)
- Li Li (ORCID: https://orcid.org/0009-0003-4636-9487)
- Meng Shen (ORCID: https://orcid.org/0000-0002-0570-1020)
- Yu Zeng (ORCID: https://orcid.org/0000-0003-4432-6443)
- Xiaohe Zhao
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1186/s12967-025-06485-4
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City
- Tianjin Science and Technology Program