Successful management of Lomentospora prolificans septic arthritis and osteomyelitis in an immunocompetent child: A case report
Available online We report a case of limb-threatening <i>Lomentospora prolificans</i> elbow infection in a 3-year-old immunocompetent boy following a closed fracture. Resolution of infection was achieved following combined aggressive debridement, combined antifungal therapy, voriconazole-loaded bone cement, and antiseptic joint irrigation. This highlights the need for early diagnosis and multi-modal surgical, medical and other novel adjunctive therapies in managing these difficult-to-treat infections. Increased research and improved access to novel antifungal drugs are essential to enhance treatment options for intrinsically multidrug-resistant fungal infections.
Authors
- Pamela Palasanthiran (ORCID: https://orcid.org/0000-0002-1625-4051)
- Burton W. Rockliff
- R. Duguid (ORCID: https://orcid.org/0000-0002-7582-6603)
- Adam Bartlett (ORCID: https://orcid.org/0000-0002-7532-9316)
- Brendan McMullan (ORCID: https://orcid.org/0000-0001-5144-3416)
- Niall Johnston (ORCID: https://orcid.org/0000-0002-2146-3253)
- Phoebe Cm Willams
Institutions
- The University of Sydney (AU)
- New South Wales Department of Health (AU)
- UNSW Sydney (AU)
- Sydney Children's Hospital (AU)
- National Centre for Immunisation Research & Surveillance (AU)
Publication Details
- Journal
- Medical Mycology Case Reports
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.mmcr.2025.100704
- Citations
- 2
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 2.79