Lung Function Trajectory Using Race-Specific vs Race-Neutral Global Lung Function Initiative Coefficients
This cohort study found that Black patients whose lung function was recategorized from normal to abnormal using the GLI Global reference equation exhibited FEV1 decline similar to that in Black patients whose lung function was classified as abnormal regardless of which equation was used. This finding suggests that a race-neutral approach to spirometry interpretation may allow a more accurate identification of lung pathology in Black patients.
Authors
- Sophia Zhao (ORCID: https://orcid.org/0009-0008-6914-3583)
- Crystal M. North (ORCID: https://orcid.org/0000-0002-6615-5385)
- Robert H. Brown (ORCID: https://orcid.org/0000-0001-6062-1528)
- Kathryn A. Hibbert (ORCID: https://orcid.org/0000-0001-7908-5446)
- Josanna Rodriguez‐Lopez (ORCID: https://orcid.org/0000-0003-2637-0563)
- C. Corey Hardin (ORCID: https://orcid.org/0000-0002-4074-0420)
- Darshali A. Vyas (ORCID: https://orcid.org/0000-0002-3709-8078)
- Eric P. Schmidt (ORCID: https://orcid.org/0000-0002-7360-0504)
- Peggy S. Lai (ORCID: https://orcid.org/0000-0001-9501-8606)
Institutions
- Massachusetts General Hospital (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.7304
- Citations
- 6
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 9.11
Funders
- Massachusetts General Hospital
- Harvard University
- Harvard Catalyst
- National Institutes of Health
- National Center for Advancing Translational Sciences