Initial Safety and Physiological Impacts of Propolis Inhalation as a Key Component of Apiair Therapy

Objective: Recently, interest in beehive air inhalation therapy, also known as Apiair, has increased significantly. Despite this, clinical studies examining its effects remain limited. Propolis, a key component found in hive air, has been identified as playing an important role in potential therapeutic benefits. This study aims to evaluate the safety and physiological effects of propolis-water extract inhalation in healthy individuals. Materials and Methods: A total of 20 healthy participants were randomly assigned to one of two groups in a double-blind trial. The first group inhaled a saline solution, while the second group received a propolis-water extract. Participants underwent pulmonary function testing, venous blood gas analysis, and electrocardiogram (ECG) monitoring before and after inhalation. Results: All physiological parameters, including pulmonary function, blood gas, and ECG measurements, remained within clinically normal limits in both groups. No adverse events were reported during the study period. Conclusion: Propolis-water extract inhalation was found to be safe in healthy individuals, with no significant deviations in clinical measures. These findings support the safety of propolis inhalation and provide a foundation for further research into its therapeutic potential in respiratory health, contributing to a broader understanding of Apiair applications.