Discrete-time competing-risks regression with or without penalization

Many studies employ the analysis of time-to-event data that incorporates competing risks and right censoring. Most methods and software packages are geared towards analyzing data that comes from a continuous failure time distribution. However, failure-time data may sometimes be discrete either because time is inherently discrete or due to imprecise measurement. This paper introduces a new estimation procedure for discrete-time survival analysis with competing events. The proposed approach offers a major key advantage over existing procedures and allows for straightforward integration and application of widely used regularized regression and screening-features methods. We illustrate the benefits of our proposed approach by a comprehensive simulation study. Additionally, we showcase the utility of the proposed procedure by estimating a survival model for the length of stay of patients hospitalized in the intensive care unit, considering 3 competing events: discharge to home, transfer to another medical facility, and in-hospital death. A Python package, PyDTS, is available for applying the proposed method with additional features.

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Publication Details

Journal
Biometrics
Published
2025-04-02
DOI
https://doi.org/10.1093/biomtc/ujaf040
Citations
1
Primary Topic
Statistical Methods and Inference
Type
article
Field-Weighted Citation Impact
2.63

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article

Discrete-time competing-risks regression with or without penalization

Tomer Meir, Malka Gorfine
1 citations
Biometrics
Statistical Methods and Inference
2.63
article

Discrete-time competing-risks regression with or without penalization

Tomer Meir, Malka Gorfine
article en
1 citations

Abstract

Many studies employ the analysis of time-to-event data that incorporates competing risks and right censoring. Most methods and software packages are geared towards analyzing data that comes from a continuous failure time distribution. However, failure-time data may sometimes be discrete either because time is inherently discrete or due to imprecise measurement. This paper introduces a new estimation procedure for discrete-time survival analysis with competing events. The proposed approach offers a major key advantage over existing procedures and allows for straightforward integration and application of widely used regularized regression and screening-features methods. We illustrate the benefits of our proposed approach by a comprehensive simulation study. Additionally, we showcase the utility of the proposed procedure by estimating a survival model for the length of stay of patients hospitalized in the intensive care unit, considering 3 competing events: discharge to home, transfer to another medical facility, and in-hospital death. A Python package, PyDTS, is available for applying the proposed method with additional features.

BiometricsVol. 81(2)
Tel Aviv University (IL), Technion – Israel Institute of Technology (IL)
Iowa Science Foundation
Peace, Justice and strong institutions
Openalex Percentile: Top 12%
Statistical Methods and Inference
2.63
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