Comparison of cardiac troponin assays reveals assay-specific sensitivities in a clinical model of very acute myocardial injury
The Atellica assay demonstrated enhanced sensitivity for very acute myocardial injury, likely via its additional recognition of the proximally located cTnI epitope. This suggests its potential to improve differentiation of acute from chronic myocardial injury, warranting further investigation to confirm its clinical utility in that setting.
Authors
- Raphael Twerenbold (ORCID: https://orcid.org/0000-0003-3814-6542)
- J T Neumann
- Andreas Rillig (ORCID: https://orcid.org/0000-0003-3457-0936)
- Laura Rottner (ORCID: https://orcid.org/0000-0002-1389-8564)
- Stefan Blankenberg (ORCID: https://orcid.org/0000-0001-6488-2362)
- J Rieß (ORCID: https://orcid.org/0009-0005-5595-4391)
- Thomas Renné (ORCID: https://orcid.org/0000-0003-4594-5975)
- Nils A. Sörensen (ORCID: https://orcid.org/0000-0002-7571-4847)
- Tanja Zeller (ORCID: https://orcid.org/0000-0003-3379-2641)
- Paulus Kirchhof (ORCID: https://orcid.org/0000-0002-1881-0197)
- Laura C. Sommerfeld (ORCID: https://orcid.org/0000-0001-9837-8770)
- Larissa Fabritz (ORCID: https://orcid.org/0000-0002-9241-1733)
- Sebastian Jäckle (ORCID: https://orcid.org/0000-0002-9258-4888)
- Julius Obergassel (ORCID: https://orcid.org/0000-0002-3905-0203)
- Marc D. Lemoine (ORCID: https://orcid.org/0000-0002-3799-7962)
- Andreas Metzner (ORCID: https://orcid.org/0000-0002-2036-3795)
- Salah Al-Aqili
Institutions
- Royal College of Surgeons in Ireland (IE)
- Universität Hamburg (DE)
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- German Centre for Cardiovascular Research (DE)
- University of Birmingham (GB)
Publication Details
- Journal
- European Heart Journal Acute Cardiovascular Care
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1093/ehjacc/zuaf064
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.39