Targeting tsRNA-1797 Alleviates Diabetes-Induced Vascular Dysfunction Through Modulating Purine Metabolism
tsRNA-1797 is a key regulator of diabetes-induced retinal vascular dysfunction. Overexpression of tsRNA-1797 exacerbates retinal vascular dysfunction in diabetes. tsRNA-1797 disrupts purine metabolism in retinal vascular endothelial cells. tsRNA-1797 directly targets CD73, reducing adenosine production and causing retinal vascular dysfunction in diabetic retinopathy.
Authors
- Qin Jiang (ORCID: https://orcid.org/0000-0002-0689-8304)
- Biao Yan (ORCID: https://orcid.org/0000-0002-7338-6413)
- Lingjie Kong (ORCID: https://orcid.org/0000-0002-8250-7547)
- Jingyue Zhang (ORCID: https://orcid.org/0000-0002-7137-9148)
- Wan Mu
- Ling Ren (ORCID: https://orcid.org/0009-0003-4941-364X)
- Duo Li (ORCID: https://orcid.org/0000-0001-5227-5565)
- Ying Zhang (ORCID: https://orcid.org/0000-0003-4363-5666)
- Xiaoyan Han (ORCID: https://orcid.org/0000-0001-7016-8659)
- Mudi Yao (ORCID: https://orcid.org/0000-0002-9856-5477)
Institutions
- Shanghai Jiao Tong University (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Shanghai First People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Diabetes
- Published
- 2025-04-24
- DOI
- https://doi.org/10.2337/db24-1158
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00