Relative Contribution of Pharmacokinetics and Immune Signatures to Clinical Outcomes in Patients With HIV-associated Cryptococcal Meningitis
Favorable clinical outcomes from HIV-associated cryptococcal meningitis are associated with coordinated inflammatory and cytotoxic responses in the central nervous system. Antifungal drug exposure was the dominant predictor of EFA.
Authors
- Melanie Moyo (ORCID: https://orcid.org/0000-0002-0483-4817)
- Reya V. Shah (ORCID: https://orcid.org/0009-0003-6678-2885)
- Thomas S. Harrison (ORCID: https://orcid.org/0000-0003-3619-4348)
- David Stephen Lawrence (ORCID: https://orcid.org/0000-0002-5439-4039)
- Henry Charles Mwandumba (ORCID: https://orcid.org/0000-0003-4470-3608)
- Madalitso Chasweka
- Cheusisime Kajanga (ORCID: https://orcid.org/0000-0002-7255-3507)
- William Hope (ORCID: https://orcid.org/0000-0001-6187-878X)
- Dumizulu Tembo
- Chandni Sarker
- Katharine E. Stott (ORCID: https://orcid.org/0000-0001-7079-7957)
- Joseph N Jarvis (ORCID: https://orcid.org/0000-0003-1459-5554)
- David G. Lalloo (ORCID: https://orcid.org/0000-0001-7680-2200)
- Wezi Chimang'anga
- Dumisan Namakhwa
- Ruwanthi Kolamunnage‐Dona (ORCID: https://orcid.org/0000-0003-3886-6208)
- Ajisa Ahmadu
- Ebbie Gondwe
Institutions
- University of London (GB)
- University of Liverpool (GB)
- St George's, University of London (GB)
- University of the Witwatersrand (ZA)
- Liverpool School of Tropical Medicine (GB)
- University of Exeter (GB)
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme (MW)
- Kamuzu Central Hospital (MW)
- London School of Hygiene & Tropical Medicine (GB)
- Hospital for Tropical Diseases (GB)
- Botswana Harvard AIDS Institute Partnership (BW)
- Hospital for Tropical Diseases (VN)
- Institute of Infection and Immunity (CA)
- Kamuzu University of Health Sciences (MW)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1093/ofid/ofaf190
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00