Relative Contribution of Pharmacokinetics and Immune Signatures to Clinical Outcomes in Patients With HIV-associated Cryptococcal Meningitis

Favorable clinical outcomes from HIV-associated cryptococcal meningitis are associated with coordinated inflammatory and cytotoxic responses in the central nervous system. Antifungal drug exposure was the dominant predictor of EFA.

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Publication Details

Journal
Open Forum Infectious Diseases
Published
2025-03-23
DOI
https://doi.org/10.1093/ofid/ofaf190
Primary Topic
Fungal Infections and Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Relative Contribution of Pharmacokinetics and Immune Signatures to Clinical Outcomes in Patients With HIV-associated Cryptococcal Meningitis

Melanie Moyo, Reya V. Shah, Thomas S. Harrison, David Stephen Lawrence et al.
Open Forum Infectious Diseases
Fungal Infections and Studies
article

Relative Contribution of Pharmacokinetics and Immune Signatures to Clinical Outcomes in Patients With HIV-associated Cryptococcal Meningitis

Melanie Moyo, Reya V. Shah, Thomas S. Harrison, David Stephen Lawrence, Henry Charles Mwandumba, Madalitso Chasweka, Cheusisime Kajanga, William Hope, Dumizulu Tembo, Chandni Sarker, Katharine E. Stott, Joseph N Jarvis, David G. Lalloo, Wezi Chimang'anga, Dumisan Namakhwa, Ruwanthi Kolamunnage‐Dona, Ajisa Ahmadu, Ebbie Gondwe
article en

Abstract

Favorable clinical outcomes from HIV-associated cryptococcal meningitis are associated with coordinated inflammatory and cytotoxic responses in the central nervous system. Antifungal drug exposure was the dominant predictor of EFA.

Open Forum Infectious DiseasesVol. 12(4)
University of London (GB), University of Liverpool (GB), St George's, University of London (GB), University of the Witwatersrand (ZA), Liverpool School of Tropical Medicine (GB), University of Exeter (GB), Malawi-Liverpool-Wellcome Trust Clinical Research Programme (MW), Kamuzu Central Hospital (MW), London School of Hygiene & Tropical Medicine (GB), Hospital for Tropical Diseases (GB), Botswana Harvard AIDS Institute Partnership (BW), Hospital for Tropical Diseases (VN), Institute of Infection and Immunity (CA), Kamuzu University of Health Sciences (MW)
Good health and well-being
Openalex Percentile: Top 88%
Fungal Infections and Studies
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