Tranexamic acid for trauma: optimal timing of administration based on the CRASH-2 and CRASH-3 trials

Tranexamic acid administration was found to be beneficial when given within 2 h of injury. In patients with severe traumatic brain injury, the treatment benefits may persist beyond the 2-hour window.

Authors

Itsuki Osawa (ORCID: https://orcid.org/0000-0001-7790-9130)
Tadahiro Goto (ORCID: https://orcid.org/0000-0002-5880-2968)
Ian Roberts

Institutions

University of London (GB)
Columbia University Irving Medical Center (US)
London School of Hygiene & Tropical Medicine (GB)
University of Tokyo Hospital (JP)
Institute for Medical Research (AR)
The University of Tokyo (JP)
Yokohama City University (JP)

Publication Details

Journal: British journal of surgery
Published: 2025-03-28
DOI: https://doi.org/10.1093/bjs/znaf079
Primary Topic: Trauma and Emergency Care Studies
Type: article
Field-Weighted Citation Impact: 0.00

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article

Tranexamic acid for trauma: optimal timing of administration based on the CRASH-2 and CRASH-3 trials

Itsuki Osawa, Tadahiro Goto, Ian Roberts

Mar 28, 2025

British journal of surgery

Trauma and Emergency Care Studies

article

Tranexamic acid for trauma: optimal timing of administration based on the CRASH-2 and CRASH-3 trials

Itsuki Osawa, Tadahiro Goto, Ian Roberts

March 28, 2025article en

Abstract

Tranexamic acid administration was found to be beneficial when given within 2 h of injury. In patients with severe traumatic brain injury, the treatment benefits may persist beyond the 2-hour window.

British journal of surgeryVol. 112(4)

University of London (GB), Columbia University Irving Medical Center (US), London School of Hygiene & Tropical Medicine (GB), University of Tokyo Hospital (JP), Institute for Medical Research (AR), The University of Tokyo (JP), Yokohama City University (JP)

Good health and well-being

Openalex Percentile: Top 86%

Trauma and Emergency Care Studies

DOI Source OpenAlex

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Tranexamic acid for trauma: optimal timing of administration based on the CRASH-2 and CRASH-3 trials — Itsuki Osawa, Tadahiro Goto, et al. · British journal of surgery (2025) | TGRS Research Map | TGRS