LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis
LGR6 significantly contributes to the protective effects on IVDD by modulating macrophage efferocytosis, enhancing ECM synthesis, and reducing apoptosis in NPCs. These findings highlight that LGR6 could be a promising therapeutic target for IVDD, with its dual role in regulating immune responses and preserving tissue integrity. Future studies are necessary to evaluate the clinical potential of LGR6-based therapies in treating degenerative disc diseases.
Authors
- Bing Zheng (ORCID: https://orcid.org/0000-0002-6098-7092)
- Kaiqiang Sun (ORCID: https://orcid.org/0000-0002-0272-8383)
- Jingchuan Sun (ORCID: https://orcid.org/0000-0002-8956-9409)
- Jiangang Shi (ORCID: https://orcid.org/0000-0003-2133-0108)
- Jun Chen (ORCID: https://orcid.org/0000-0002-3850-4875)
- Fudong Li (ORCID: https://orcid.org/0000-0002-3407-0715)
- Yangyang Shi
Institutions
- Shanghai Changzheng Hospital (CN)
- Shanghai Zhabei District Shibei Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1186/s12967-025-06427-0
- Citations
- 10
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 14.72
Funders
- National Natural Science Foundation of China
- Shanghai Hospital Development Center