Functionalized Oxindole Construction via a Cyano Migration and Cyclization Relay Strategy
A visible-light-induced trifunctionalization of unactivated alkenes for building functionalized oxindoles through a radical cyano migration strategy is reported. This transformation employs a tandem alkene sulfonylation-initiated cyano migration/cyclization cascade process. This strategy features stable and easily accessible substrates, mild reaction conditions, metal-free catalysts, and the capability of late-stage functionalization.
Authors
- Shun‐Yi Wang (ORCID: https://orcid.org/0000-0002-8985-8753)
- Feng Zhou (ORCID: https://orcid.org/0000-0002-6729-1311)
- Weidong Rao (ORCID: https://orcid.org/0000-0002-6088-7278)
- Bo-Xi Liu
- Syed Anis Ali Shah
- Daopeng Sheng
- Shusu Shen (ORCID: https://orcid.org/0000-0003-2307-999X)
Institutions
- Nanjing Forestry University (CN)
- Suzhou University of Science and Technology (CN)
- Laboratoire de Synthèse Organique (FR)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1021/acs.orglett.5c00899
- Citations
- 2
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Cyrus Tang Foundation
- National Natural Science Foundation of China
- Soochow University
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Qinglan Project of Jiangsu Province of China