Epigenetic modulation of the NLRP6 inflammasome sensor as a therapeutic modality to reduce necroptosis-driven gastrointestinal mucosal dysfunction in HIV/SIV infection
We conclude that DNA hypomethylation-assisted NLRP6 upregulation can lead to its constitutively high expression resulting in the activation of necroptosis signaling via the RIPK3/p-MLKL pathway that can eventually drive intestinal epithelial loss/death. From a clinical standpoint, low-dose phytocannabinoids in combination with ART could safely and successfully reduce/reverse persistent GI inflammatory responses via modulating DNA methylation.
Authors
- Lakmini S. Premadasa (ORCID: https://orcid.org/0000-0001-7435-5208)
- Binhua Ling (ORCID: https://orcid.org/0000-0002-2259-8889)
- Mahesh Mohan (ORCID: https://orcid.org/0000-0003-4360-3277)
- Marina McDew‐White (ORCID: https://orcid.org/0000-0001-7821-260X)
- Chioma M. Okeoma (ORCID: https://orcid.org/0000-0001-7737-6493)
- Luis Romero (ORCID: https://orcid.org/0009-0004-7768-5965)
- Beverly Gondo
- Jade A. Drawec
Institutions
- Texas Biomedical Research Institute (US)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1186/s12964-025-02193-0
- Citations
- 5
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.03