A novel INDEL-based next-generation sequencing assay for monitoring donor-derived cell-free DNA in renal transplant recipients—from bedside to results: a UK pilot study
The INDEL-based NGS assay is a promising novel tool for detecting and monitoring dd-cfDNA in renal transplant recipients with an easy-to-implement workflow. These preliminary results support its clinical utility in a high-immunological-risk setting. These findings are consistent with emergent literature; however, longitudinal data and further validation in a larger cohort of patients are required.
Authors
- Sanjay Mehra (ORCID: https://orcid.org/0000-0002-9792-3375)
- Abdul Hammad (ORCID: https://orcid.org/0000-0002-4952-0096)
- Petra Goldsmith (ORCID: https://orcid.org/0000-0003-0683-448X)
- Andrew R. Jones (ORCID: https://orcid.org/0000-0001-6118-9327)
- Matthew Howse (ORCID: https://orcid.org/0000-0001-8057-8707)
- Fotini Partheniou
- Dan Ridgway
- G E Nita (ORCID: https://orcid.org/0000-0002-5637-2044)
Institutions
- University of Liverpool (GB)
- Royal Liverpool University Hospital (GB)
Publication Details
- Journal
- Clinical Transplantation and Research
- Published
- 2025-04-25
- DOI
- https://doi.org/10.4285/ctr.25.0004
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00